SGP50 新一代抗体偶联ADC linker

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SGP50
这个产品是新一代的ADC Linker,最快的进度在二期临床,属于best-in-class。

对于高效制备高纯度唾液酸糖肽(Sialylglycopeptide)的新选择。
描述:
唾液酸糖肽(SGP)是一种N-连接糖肽,是鸡蛋黄的主要成分之一。SGP及其相关物质因具有双天线结构的聚糖和唾液酸寡糖而展现出有效的抗菌和抗病毒特性。众多研究致力于通过修饰聚糖来提高其在血液中的反应性和稳定性,以进行药物设计。然而,天然存在的聚糖是异质且复杂的混合物。由于这一特性,合成均质聚糖曾被认为是一项难题。

应用:
在许多研究中,基于SGP的衍生物展现出开发成新型病毒和细菌感染预防药物的潜力。同时,由于其结构简单且结合能力强,这种仿生受体可以成为糖科学领域的一种多功能工具。特别地,它被应用于抗体药物偶联物(ADC)的制备中,通过抗体上的聚糖作为新型接头。

优势:
由于鸡蛋中SGP含量较低且制备过程成本较高,因此高价限制了SGP产品的应用。现在,该产品(含50%SGP)可以以公斤级容量供应,将以具有竞争力的成本提高您高纯度产品的制备效率。
此外,该工艺中未使用酚或其他添加剂,仅使用了一种有机溶剂乙醇。

运输信息:
来源:100%巴氏杀菌鸡蛋黄粉
CAS号:189035-43-6
规格:
Specifications

Test item Specification Method
Appearance外观 White to light yellow powder白色至浅黄色粉末 /
Odor气味 Slight eggyolk smell轻微蛋黄味 /
Moisture水分 ≤10.0% Karl Fischer卡尔·费休法
Content含量 ≥50.0% HPLC External Standard,Dry Basis高效液相色谱外标法,干基
Ash灰分 ≤3.0% Residue on ignition‌灼烧残渣法
Total numbers of colony菌落总数 ≤5000CFU/g Plate count 平板计数法
 

包装和储存:
包装:1克、10克、100克、1千克。
交货时间:<100克,现货供应;≥100克,3~4周。
储存条件:-20℃。
保质期:2年(暂定值,保质期测试正在进行中)。

以下是给更熟悉英文的朋友看的内容
Here's the English version for your friends who are more familiar with English
 

New choice for efficient preparation of high purity Sialylglycopeptide.

Description
The Sialylglycopeptide(SGP) is an N-linked glycopeptide as a main component of hen’s egg yolk. SGP and its related substances have effectively antimicrobial and antiviral properties because of the bi-antennary structure of glycans and sialo-oligosaccharides. Many researches have been conducted to research the drug design for increasing reactivity and stability in the blood by modification of glycans.However, naturally occurred glycans are heterogeneous and complexed mixture. Due to this character, synthesizing homogenous glycans were thought to be difficult.
Applications
In many studies,the derivatives based on SGP reveal the potential to be developed into new prophylactic drugs of viral and bacterial infections.Meanwhile,because of the simple structure and the remarkable binding ability, this biomimetic receptor can represent a versatile tool for glycoscience.In particular, it is applied to ADC (Antibody-Drug Conjugate) preparation via glycans on the antibody as a novel linker.
Advantages
Due to the low content in eggs and the high cost in preparation process,the high price restricts the application of the SGP products.Now the product, contents 50%SGP, can be supplied with KGs capacity, it will improve the preparation efficiency at a competitive cost for your high purity products.
Moreover,neither Phenol nor other additive,only one organic solvent ethanol,was used.
Shipping Information
Source: 100% Pasteurized Egg Yolk Powder
CAS No.: 189035-43-6
Specifications
Test item Specification Method
Appearance White to light yellow powder /
Odor Slight eggyolk smell /
Moisture ≤10.0% Karl Fischer
Content ≥50.0% HPLC External Standard,Dry Basis
Ash ≤3.0% Residue on ignition‌
Total numbers of colony ≤5000CFU/g Plate count 
 
 
Packaging and Storage
Packaging: 1g, 10g, 100g, 1kg.
Delivery time:<100g,Spot supplies,≥100g, 3~4 weeks.
Storage: -20℃.
Expiry: 2 years (Provisional value,shelf-life testing is on-going).